Simmonds' Disease

Simmonds' Disease

In 1907 Paulesco demonstrated that removal of that pituitary gland caused weakness, loss of weight and death. In 1914 Simmonds reported the first case of the disease called after his name. A woman aged 38 years, after recovering from puerperal sepsis, developed amenorrhcea, increasing weakness, progressive loss of weight, anaemia, and premature senility. He put it down to atrophic degeneration ...

Cachexia Hypophysio-Priva (Simmonds' Disease). (Describing a Case Cured under Treatment)

Management of Hereditary Breast Cancer

D.M. Eccles, P. Simmonds, J. Goddard, M. Coultas, F. Lalloo, G. Evans and N. Haites in collaboration with the European Familial Breast Cancer Collaborative Group Department of Clinical Genetics, Princess Ann Hospital, Coxford Road, Southampton, UK Medical Oncology, Royal South Hants Hospital, Southampton, UK Medical Statistics and Computing, Southampton General Hospital, Southampton, UK Clinica...

Nitrogen Retention, Creatinuria, and Other Effects of the Treatment of Simmonds' Disease with Methyl Testosterone.

One of the immediate effects of hypophysectomy is a loss of nitrogen (1) and a corresponding loss in weight (2). This change is reflected clinically by the so-called cachexia of Simmonds' disease (3). Nitrogen balance is then re-established at a lower level of body weight with lessened food intake. In the experimental animal, adequate replacement therapy is readily obtained with anterior hypoph...

Lymphadenopathy in coeliac disease.

We present two cases of adult coeliac disease whose major clinical feature was marked lymphadenopathy. One patient also displayed a peripheral lymphocytosis which varied with treatment of the underlying disease.

High frequency of parvovirus B19 in patients tested for rheumatoid factor.